جمعه 14 تیر 1398  05:46 ب.ظ

Grapiprant | EP4 Receptor antagonist

Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5

References/Citations

1) Nakao et al. (2007), CJ-023,423, a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties; J. Pharmacol. Exp. Ther. 332 686
2) Okumura et al. (2008), Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis; J. Pharm. Pharmacol. 60 7235
3) Chen et al. (2010), A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models; Br. J. Pharmacol. 160 292
4) Wang and DuBois (2016), Wang and DuBois (2016), The Role of Prostaglandin E2 in Tumor-Associated Immunosuppression; Trends Mol. Med. 22 1
5) NCT03696212 and NCT03658772


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Lunar Robotic Mission Heracles Will Scout for Human Landings

NASA's push to return humans to the moon will get a huge international helping hand. A mission named Heracles will use a robotic rover to survey the lunar terrain in preparation for the eventual arrival of astronauts and to return samples it scooped up to Earth.Robotic Manufacturer

The European-Canadian-Japanese mission, scheduled for the mid- to late 2020s, calls for the rover to arrive on the moon inside a small lander, under the careful watch of astronauts in NASA's planned Gateway space station. Gateway will orbit the moon and allow astronauts and robots easier access to the lunar surface.

The rover, ESA said in a statement, will examine the terrain and pick up several samples, which it will return to its lander. Then the spacecraft's ascent module will head to Gateway bearing the precious lunar rocks and regolith (soil).

The ultimate goal of Heracles is to return lunar samples to Earth during Orion's fourth or fifth mission. Those Orion missions would be part of the so-called Artemis program, NASA's initiative under President Donald Trump's administration to land humans on the moon by 2024. But ESA doesn't appear to be working under the same timeline, with their would-be preparatory mission coming as or after NASA attempts to land astronauts.

But the robots won't be done then. Once the ascent module arrives back at Gateway, Canadarm3 — a robotic arm planned by the Canadian Space Agency — will capture the spacecraft. The Canadarm3 will then berth the spacecraft to the outpost's airlock so that the moon samples can be brought inside NASA's Orion spacecraft, which the agency plans to test for the first time in 2020.
https://www.crprobotic.com/industrialroboticnews/295.html


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جمعه 14 تیر 1398  05:29 ب.ظ

If the shine has come off your favourite piece of bling, there’s no need to consign it to the bottom of the Cheap Jewelry Sites box. It’s pretty easy to make your baubles look as good as new – all that’s needed is some scrubbing action and knowing which cleaner to use.

Cheap costume jewellery benefits from cleaning as much as more expensive metals. All it needs is a gentle scrub with some toothpaste and an old soft-bristle toothbrush. The baking soda in toothpaste will help rub off the dirt.

After scrubbing the jewellery for five to 10 minutes, rinse with warm water and dry thoroughly with a dry cloth. Avoid gel toothpastes or ones that contain whitening or tartar-control chemicals, as they may damage the metal.

Over time, silver can develop a depressingly dull finish. The scrubbing method is a tad too abrasive here, but a surprisingly easy hands-free technique does exist: all you need is water, salt, tinfoil and bicarbonate of soda.

Cover a plate with a sheet of tinfoil and add one tablespoon each of salt and bicarbonate. Next, pour one cup of hot water (not boiling) over the mixture and stir gently to dissolve. Place your jewellery into the solution and leave for 10 minutes – the combination of salt, bicarbonate and aluminium creates a chemical reaction that oxidises the tarnish straight off your silver. Science is magic, see?
While gold doesn’t tarnish as easily as silver, it can accumulate grime and dirt with regular use. The toothpaste method works ace here, but you can also use good old-fashioned dishwashing liquid. Squirt a few drops of detergent into a bowl of warm water and leave your gold jewellery to soak for 15 minutes. Scrub it with an old toothbrush and then rinse in warm water before blotting dry.

If your jewellery has stones glued into their setting (like most earrings), you’ll need to take extra care when cleaning. These shouldn’t be submerged in warm water, as this may loosen the glue and cause them to drop out. Spot clean the gems by wiping them with a cloth soaked in some soapy water; next, wipe off the suds with a cloth dampened with water. Dry thoroughly.

While hard stones such as diamonds, rubies and imitation gems (read: those flashy cheap rhinestones) are pretty hardy, special treatment is needed for softer stones such as


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جمعه 14 تیر 1398  05:21 ب.ظ

How To Clean Even Your Cheapest Jewellery

If the shine has come off your favourite piece of bling, there’s no need to consign it to the bottom of the Cheap Jewelry Sites box. It’s pretty easy to make your baubles look as good as new – all that’s needed is some scrubbing action and knowing which cleaner to use.

Cheap costume jewellery benefits from cleaning as much as more expensive metals. All it needs is a gentle scrub with some toothpaste and an old soft-bristle toothbrush. The baking soda in toothpaste will help rub off the dirt.

After scrubbing the jewellery for five to 10 minutes, rinse with warm water and dry thoroughly with a dry cloth. Avoid gel toothpastes or ones that contain whitening or tartar-control chemicals, as they may damage the metal.

Over time, silver can develop a depressingly dull finish. The scrubbing method is a tad too abrasive here, but a surprisingly easy hands-free technique does exist: all you need is water, salt, tinfoil and bicarbonate of soda.

Cover a plate with a sheet of tinfoil and add one tablespoon each of salt and bicarbonate. Next, pour one cup of hot water (not boiling) over the mixture and stir gently to dissolve. Place your jewellery into the solution and leave for 10 minutes – the combination of salt, bicarbonate and aluminium creates a chemical reaction that oxidises the tarnish straight off your silver. Science is magic, see?
While gold doesn’t tarnish as easily as silver, it can accumulate grime and dirt with regular use. The toothpaste method works ace here, but you can also use good old-fashioned dishwashing liquid. Squirt a few drops of detergent into a bowl of warm water and leave your gold jewellery to soak for 15 minutes. Scrub it with an old toothbrush and then rinse in warm water before blotting dry.

If your jewellery has stones glued into their setting (like most earrings), you’ll need to take extra care when cleaning. These shouldn’t be submerged in warm water, as this may loosen the glue and cause them to drop out. Spot clean the gems by wiping them with a cloth soaked in some soapy water; next, wipe off the suds with a cloth dampened with water. Dry thoroughly.

While hard stones such as diamonds, rubies and imitation gems (read: those flashy cheap rhinestones) are pretty hardy, special treatment is needed for softer stones such as pearls. Check this chart for what kind of cleaning methods your precious gems require.


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Coated steel cable from Carl Stahl TECHNOCABLES: an overview of the benefits to you

For example, in the case of cable systems that run over pulleys, we recommend using coated cables in order to achieve a high bending cycle and a long service life. With higher bending cycles a longer service life could be achieved.zinc coated steel wire strand
Carl Stahl Technocables uses polyamide as the standard coating material. Polyamide is an optimum cable coating, distinguished by its high wear resistance and high bending cycle capability. A further advantage of the coated cables: The coating protects the rope from dirt.
We recommend PA12 if the cable runs over a pulley or if flexibility is the main priority. This is our standard coating material.
Furthermore, the coating keeps the manufacturing lubricant within the rope. This film of oil functions as a lubricant between the individual wires and strands, thereby reducing wear on the cable.
Are high temperatures or good sliding properties required of your steel wire rope? Then we use special materials for coating of the steel wire rope. For example, we recommend FEP/PTFE for temperatures of between -190°C and + 205° C.
We can also offer PA6. PA6 is stiffer than PA12 and is therefore not suitable for pulleys. However, PA6 has better sliding properties and is therefore highly suitable as a guide cable for example.
Depending on the application, the appropriate coating material is used. Don’t you know which wire rope coating is the right for your rope application? - We're glad to help you finding the right material.


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جمعه 14 تیر 1398  05:02 ب.ظ

Carbon Steel Wire

Carbon steel is steel in which the main interstitial alloying constituent is carbon in the range of 0.12–2.0%. The American Iron and Steel Institute (AISI) definition says: Steel is considered to be carbon steel when no minimum content is specified or required for chromium, cobalt, molybdenum, nickel, niobium, titanium, tungsten, vanadium or zirconium, or any other element to be added to obtain a desired alloying effect; when the specified minimum for copper does not exceed 0.40 percent; or when the maximum content specified for any of the following elements does not exceed the percentages noted: manganese 1.65, silicon 0.60, copper 0.60. The term "carbon steel" may also be used in reference to steel which is not stainless steel; in this use carbon steel may include alloy steels. As the carbon percentage content rises, steel has the ability to become harder and stronger through heat treating; however, it becomes less ductile. Regardless of the heat treatment, a higher carbon content reduces weldability. In carbon steels, the higher carbon content lowers the melting point.carbon steel flat wire
Spring Works Utah specializes in the custom manufacture of wire springs, flat springs, and wire products using Brite Basic CA260 Carbon Steel Wire material. Our extensive inventory and design experience makes us a resource for customer requests as well as a preferred supplier to spring manufacturers worldwide. We know choosing the right material can be challenging and many times the most important aspect of your design. We will assist you in picking the best material for your specific application, all at the right price. Allow us to be your custom manufacturer utilizing Brite Basic CA260 material.


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Standard Specification for Zinc-Coated (Galvanized) Low-Carbon Steel Armor Wire

This specification covers zinc-coated low-carbon steel wire for use in armoring for protection against damage of submarine and underground cables used for communication, control, or power purposes. The base metal shall be open-hearth, basic-oxygen, or electric-furnace steel, ingot or continuous cast. The wire shall be furnished in coils of one continuous length. Welds made prior to final wire drawing shall be permitted. Mechanical properties such as tensile strength and elongation shall be measured. Also, weight and adherence of the coating shall be determined.galvanized steel wire strand
1. Scope

1.1 This specification covers zinc-coated low-carbon steel wire for use in armoring for protection against damage of submarine and underground cables used for communication, control, or power purposes.

1.2 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard.

1.3 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.


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Global Galvanized Spring Steel WireProduction Market Share

The global Galvanized Spring Steel Wire market is valued at xx million US$ in 2018 is expected to reach xx million US$ by the end of 2025, growing at a CAGR of xx% during 2019-2025.galvanized spring steel wire

This report focuses on Galvanized Spring Steel Wire volume and value at global level, regional level and company level. From a global perspective, this report represents overall Galvanized Spring Steel Wire market size by analyzing historical data and future prospect. Regionally, this report focuses on several key regions: North America, Europe, China and Japan.

Key companies profiled in Galvanized Spring Steel Wire Market report are Davis, Artsons, Seal Wire, King Steel Corporation, Hua Yuan, TianZe, Shanxi Broadwire, HF-WIRE, TianYang, Yicheng, Hongli, Antong, Zhida, Yili and more in term of company basic information, Product Introduction, Application, Specification, Production, Revenue, Price and Gross Margin (2014-2019), etc.
Table of Content

1 Galvanized Spring Steel Wire Market Overview

2 Global Galvanized Spring Steel Wire Market Competition by Manufacturers

3 Global Galvanized Spring Steel Wire Production Market Share by Regions

4 Global Galvanized Spring Steel Wire Consumption by Regions

5 Global Galvanized Spring Steel Wire Production, Revenue, Price Trend by Type

6 Global Galvanized Spring Steel Wire Market Analysis by Applications

7 Company Profiles and Key Figures in Galvanized Spring Steel Wire Business

8 Galvanized Spring Steel Wire Manufacturing Cost Analysis

9 Marketing Channel, Distributors and Customers

10 Market Dynamics

11 Global Galvanized Spring Steel Wire Market Forecast

12 Research Findings and Conclusion

13 Methodology and Data Source


  • آخرین ویرایش:جمعه 14 تیر 1398
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Triples Workforce to Meet Demand for LED Displays and Lighting

Ultravision International, a leading innovator, manufacturer and distributor of indoor and outdoor led display and LED lighting, has deepened its Made in America commitment by investing $4 million to open new manufacturing lines in Dallas, a move that will significantly expand its production capacity and triple the company’s North Texas workforce.

Ultravision, the brainchild of long-time Dallas entrepreneur William Hall, holds 39 patents for LED lighting and LED modular display panel technologies, making it an industry leader for LED products.

“Ultravision fundamentally changed the LED industry by inventing light-weight, modular display panels that eliminate the need for cabinet displays, which are difficult to install and costly to maintain,” said William Hall, CEO and co-founder of Ultravision International. “We are proud to manufacture all of our products in the United States. The incredible demand we’re experiencing across industries tells us buyers recognize the value of buying LED technology from the actual inventor and U.S. manufacturer.”

As outdoor and out-of-home advertising companies look to accelerate the change from static billboards to dynamic LED digital displays, demand for Ultravision products has skyrocketed, resulting in the need to significantly expand its manufacturing capabilities in Dallas.

The company’s new production lines can operate around the clock to keep pace with demand, and will be used to produce Ultravision’s billboard lighting assemblies and the modular LED display panels. However, all lines can be quickly retooled to manufacture the same product in the event a customer makes a large enough order to need full production capacity.

To staff the accelerated manufacturing plant, Ultravision has more than tripled its workforce by adding new production employees, with dozens more sales, marketing, administrative and management personnel expected to join the company in 2018.


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جمعه 14 تیر 1398  04:22 ب.ظ

Foot LED Display

The centerpiece of the courtyard of the $91 million Delta Hotels by Marriott Watters Creek Convention Center will be a 198 square-foot LED display manufactured by Ultravision International, a leading innovator, manufacturer and distributor of indoor fixed led display and LED lighting.

Mounted as a video wall that lights up the Delta Hotel’s entertainment courtyard, the 11 feet tall by 18 feet wide high-resolution LED display can be used for a variety of purposes from broadcasting on-site events to running advertising and marketing promotions to live-streaming sporting events for hotel and conference center guests.

Set to open in early 2019, the Delta Hotel will be the largest convention center space between Dallas and Oklahoma along U.S. Highway 75.

“The Delta opening is a game changer for Dallas’ booming business community, and it’s only right that the conference hub will feature a locally-manufactured LED display to communicate with audiences during all of the exciting events that will happen there,” said William Hall, CEO and co-founder of Ultravision International. “We couldn’t be more excited about this partnership and can’t wait to see how conference hosts and advertisers take advantage of the new LED display.”

The new Delta Hotels by Marriott – which is located at the northwest corner of U.S. 75 and Bethany Drive -- includes 300 rooms, 90,000 square feet of convention and meeting space with 1,000 parking spaces. It offers a sophisticated interpretation of the Texas urban landscape, and reflects the energy of North Dallas by blending rustic design materidals with curated art and the latest technology. It’s the first-ever Delta Hotels by Marriott in Texas and will be used as a model design for future new builds of the hotel line throughout the U.S.


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جمعه 14 تیر 1398  04:17 ب.ظ

LED Display Market With A CAGR Of 14%

The LED display market is driven by increasing awareness about energy conservation and surging use of LED technology in laptops, mobile phones, smart TVs, monitors, and other products. Moreover, the rising demand for LED displays for outdoor advertisements, promotional events sport exhibitions and other parameter also impact the growth of the LED display market. The adoption of advanced display technology will accelerate indoor full color led display screen Market. It is estimated that the total revenue generated by the LED display market will reach $23bn by 2025 and grow with a CAGR of 14% during the forecast period.

The demand for 5 Plus LED Display Screens are widely increasing as people are becoming more tech-savvy and are switching to LED displays. The latest innovations such as revolutionizing smart TVs, digital advertisements and gaming screens have provided new opportunities for LED display market. The escalating growth for flexible LED displays such as LED curtains, LED matrix and so on, has provided high resolution and a flexible rubber substrate which creates curves to the screen that enhances the customer's visual experience.
The LED displays are used in various applications such as digital advertising, lighted wallpapers, general lighting, automotive headlamps, traffic signals, and even in medical devices. Moreover, the replacement of billboards with digital signage that comprises of LEDs in many countries has raised the growth of the LED display market.

According to Infotrends' data, in 2018 most of the outdoor advertising companies have gained 32% increased sales by adopting digital signage for advertising. Also, around 30% of the customers are preferring digital signage as menu in the restaurants. The rising adoption of digital signage displays in various stores, restaurants and other public places for seeking attention of the customer has fuelled the growth of LED display market. Moreover, the increasing investments in digital signage by most of the companies to increase productivity and retain customer attention will propel the LED display market in the near future. Digital signage with LEDs is estimated to grow at a CAGR of 18% during the forecast period 2019-2025.

The Asia Pacific (APAC) is the fastest growing region and also the largest contributor to the LED display market in 2018 with a share of 36%. The APAC region comprises of countries such as Japan, South Korea, China, India, and others, which are in the process of innovating LED displays for increasing applications across various industry verticals such as consumer electronics, automotive, and others. Also, China's established hardware base and India's advancing consumer electronics industry due to increasing demand by the customer has provided growth opportunities for LED display market in APAC region.


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جمعه 14 تیر 1398  01:13 ب.ظ

P8 Outdoor Fixed Led Display Wall

P8 Outdoor Fixed led display wall Features:
High brightness:
the products adopt super-high brightness LED, so that you can see clearly from a long distance even in strong sunshine.outdoor fixed led display
Good effect:
P8 outdoor fixed led display wall adopt non-linear calibration technology to realize clearer images with stronger feeling of layers.
High reliability:
the products adopt the static scanning technology and the module design technology to offer higher reliability and stability.
Diversified display modes:
the products support multiple display modes.
Easy operation:
outdoor led display wall adopt popular video playing software to facilitate system operations.
Available range: government plazas, recreational plazas, large-scale entertainment plazas, busy business and commercial centers, ad information boards, commercial streets, and railway stations etc..
P8 Outdoor Fixed led display wall Video:


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جمعه 14 تیر 1398  01:03 ب.ظ

HOW TO CHOOSE A DURABLE USB CABLE

USB(Universal Serial Bus), was been developed in the 1990s, simplifiying the connection between computers and peripheral devices. It was widely used for data transmission like connecting computers with mobile devices to transmit files such as video, songs and pictures, as well as charging phones and external connections.Nylon Data Cable

USB Type A
USB type A is rectangular in shape, and the most popular USB cable nowadays. It is usually seen in DC, media players and smart phone charging cables.
USB Type B

Type-B connectors, at the other side of USB cable, plug into a peripheral device like hard drive and smart phone. The types of Type-B socket can be divided into standard, mini and micro. They all have same function but different socket shape design as for plugging together in the way they work.

USB Type C
Type C allows for reverse plug orientation, which means that you can plug in your USB cable correctly whether in positive or negative direction without worrying about being upside down.
USB chargers impact how fast your device's battery will be fully charged. Choose the right USB cable for your smart phone is of great important for a safe and quick charge experience. It may bring many potential safety risks to you if you choose a cheap USB cable. The main problem of charging safety is that the interface plug is not durable and will be broken due to plugging with many times after long time use. It may lead to prolonged charging time, unstable data transmission, fracture and other hidden dangers, or even lead to electronic equipment scrap or explosion.

So, it is really important for you to choose a high-quality USB cable. The following will tell you the influence factors and tips to choose a durable USB cable.


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The Best Portable Chargers on Amazon, According to Hyperenthusiastic Reviewers

Here at the Strategist, we like to think of ourselves as crazy (in the good way) about the stuff we buy, but as much as we’d like to, we can’t try everything. Which is why we have People’s Choice in which we find the best-reviewed products and single out the most convincing ones. (You can learn more about our rating system and how we pick each item here.)Fast Charge Power Bank

And while we’ve written about lots of chargers before — including one writer’s favorite light-up charger, the best wireless chargers, and the best charging stand — here we’ve rounded up the best portable chargers and power banks, as praised by the most enthusiastic reviewers on Amazon.
With over 18,000 five-star reviews, this charger is often described as compact and light, making it a favorite for travel. One frequent traveler writes, “In celebration of my seniority of 70 years, I am making my next two-month trip with just a small Marmot backpack and an Eagle Creek Load Hauler Expandable duffel. Packing weight and compactness is my primary motivation for anything I take on the next trip. One extra pound is too much for this trip, so I chose the Anker PowerCore+ Mini 3350 mAh lipstick charger, which weighs around three ounces.” Many also call this charger “reliable” and a “necessity,” like one who writes, “I absolutely trust this charger. With a surplus of portable chargers on the market, it’s difficult to identify and separate the good from the junk. I’ve tried over eight different ones and can’t say enough about this extremely reliable, user friendly, and ergonomically distinct product that can fit in your pocket.” Many who use it constantly can attest to its strength, like one who writes, “During the height of Pokémon Go, my 5-year-old and I spent hours in Central Park hunting for imaginary beasts, and I found my cell phone battery was not up to the task. I purchased this charger two months ago to help with my power needs and it delivered. I get a full charge and a half from this.”


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Best Bluetooth Sports And Fitness Earphones and Headphones 2019

If there was just one thing you could take to the gym with you, I'm pretty sure it'd be a good set of earphones. Whether that's to block out the person grunting on the squat rack next to you, or just to help distract you from the torment of going for a long run, they're definitely a fitness essential in my eyes.Sports Bluetooth Headset price

But with so many available now, how can you know which are the best type to train in? Well, wireless earphones are usually the best for any type of exercise, but still, there are literally thousands of these on the market now all promising different things, so knowing which are any good before you buy isn't easy.

Well, I've tried a bunch of the biggest headphone and earphone brands out there right now to answer this very quandary, and so here are some of the best money can buy, whether it's for running, cycling, working out in the gym or simply chilling out after.
By far my favorite pair of headphones - possibly ever - is the Earin M-2. These are easily the most subtle and slimline in-ear buds I've ever used or seen. And while that's their main sell, they are also super confortable due to their remarkable light weight, and the sound quality is just top notch. They also feel like they are noise-canceling, despite not having this technology bult in, mainly because of how far and snugly they fit into your eardrums.

They aren't waterproof, but they are beautifully designed, come in a super slick charging case that is the same size as a lipstick, and generally just a pleasure to use. A* for the M-2s!


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