دوشنبه 29 مهر 1398  07:17 ب.ظ

Coluracetam (MKC-231) is a synthetic Racetam drug purported to be a Nootropic compound. It does not have a large body of evidence investigating it, but the mechanisms of action (as well as structute) appear to be very distinct from other racetam compounds like Piracetam or Aniracetam.Coluracetam Review
Coluracetam appears to interact with a process known as high affinity choline uptake (HACU for short), which is the rate-limiting step of drawing choline into a neuron for synthesis into the neurotransmitter acetylcholine. Increasing the HACU rate appears to increase the activity of cholinergic neurons, so it is a desired target for cognitive enhancement.

Interventions in rats (as there is no human evidence currently) support the usage of coluracetam at very low oral doses to preserve HACU that is otherwise impaired by the use of research drugs that are known to impair HACU. The limited evidence looking at the inherent effects of coluracetam on the HACU of normal neurons has failed to find any significant interaction.
Coluracetam has also been noted to associate with choline transporters physically, but it is not known exactly what it does once associated.

Overall, there is currently insufficient evidence to support the usage of coluracetam for cognitive enhancement. Further studies are needed to see if it has a therapeutic role in instances where HACU may be impaired (such as Alzheimer’s disease).

Application:

Rat studies have shown that Coluracetam is helpful in reducing the effects of learning deficits. Not only did it reduce these effects, but it also did not have any of the normally expected side effects [4]. This product is also considered to have great potential as a casual mood enhancer and a powerful memory booster. There is even evidence to suggest that the positive effects on the brain are semi-permanent [5].
Users also report a rather wide range of Coluracetam benefits. This includes enhanced concentration and speed of cognition. Coluracetam also helps with both short and medium term memory. There are also a number of reports of being able to study and focus more easily while taking this nootropic

Description:

Coluracetam also seems to have a bit of a stimulant effect. It should help to shake off any of the morning dreariness if taken upon waking and it may produce a nice, comfortable energy boost that can last well into the day. A number of users have reported that this is able to help them improve their motivation and ability to get things done. Another interesting effect is the apparent enhancement of sounds and colors. This can be compared to turning up the brightness on a TV or computer screen, with sounds become fuller and richer

Coluracetam Dosage:

Coluracetam is a rather fast acting nootropic that can be detected in neural tissues within 30 minutes of ingestion [5]. Suggested dosage is 48-480mcg/kg. This means 3.2-32.7mg for a 200lb person


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